EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.B43 | 5-[(5-[[(benzyloxy)carbonyl]amino]-6-[(diphenylmethyl)amino]-6-oxohexyl)amino]-5-sulfanylidenepentanoic acid | - |
Homo sapiens | |
2.3.1.B43 | 5-[(5-[[(benzyloxy)carbonyl]amino]-6-[[(naphthalen-1-yl)methyl]amino]-6-oxohexyl)amino]-5-sulfanylidenepentanoic acid | - |
Homo sapiens | |
2.3.1.B43 | 5-[(5-[[(benzyloxy)carbonyl]amino]-6-[[2-(1H-indol-3-yl)ethyl]amino]-6-oxohexyl)amino]-5-sulfanylidenepentanoic acid | - |
Homo sapiens | |
2.3.1.B43 | 5-[(6-amino-5-[[(benzyloxy)carbonyl]amino]-6-oxohexyl)amino]-5-sulfanylidenepentanoic acid | - |
Homo sapiens | |
2.3.1.B43 | 5-[(6-[(1,3-benzothiazol-5-yl)amino]-5-[[(benzyloxy)carbonyl]amino]-6-oxohexyl)amino]-5-sulfanylidenepentanoic acid | - |
Homo sapiens | |
2.3.1.B43 | 5-[(6-[(adamantan-1-yl)amino]-5-[[(benzyloxy)carbonyl]amino]-6-oxohexyl)amino]-5-sulfanylidenepentanoic acid | - |
Homo sapiens | |
2.3.1.B43 | 5-[[5-[[(benzyloxy)carbonyl]amino]-6-oxo-6-([(1S)-2-oxo-1-phenyl-2-[(propan-2-yl)amino]ethyl]amino)hexyl]amino]-5-sulfanylidenepentanoic acid | - |
Homo sapiens | |
2.3.1.B43 | additional information | the acyl-substrate specificity of SIRT5 is adapted to selectively inhibit this isozyme. Synthesis and evaluation of mechanism-based inhibitors of SIRT5, structure-activity relationship, overview | Danio rerio | |
2.3.1.B43 | additional information | the acyl-substrate specificity of SIRT5 is adapted to selectively inhibit this isozyme. Synthesis and evaluation of mechanism-based inhibitors of SIRT5, structure-activity relationship, overview | Homo sapiens | |
2.3.1.B43 | N-[(7S)-7-[[(benzyloxy)carbonyl]amino]-8-([(2S)-3-(1H-indol-3-yl)-1-oxo-1-[(propan-2-yl)amino]propan-2-yl]amino)-8-oxooctanoyl]-beta-alanine | - |
Homo sapiens | |
2.3.1.B43 | N-[(benzyloxy)carbonyl]-5-[2-(4-carboxybutanoyl)hydrazinyl]-L-norvalyl-N-propan-2-yl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N2-(benzenesulfonyl)-N6-[(2-carboxyethyl)carbamothioyl]-L-lysyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N2-(benzylcarbamoyl)-N6-[(2-carboxyethyl)carbamothioyl]-L-lysyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N2-benzoyl-N6-[(2-carboxyethyl)carbamothioyl]-L-lysyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-(4-carboxy-2,2-difluorobutanoyl)-L-lysyl-N-propan-2-yl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-(4-carboxybutanethioyl)lysyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-(4-carboxybutanethioyl)lysyl-L-tryptophyl-L-aspartamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-(4-carboxybutanethioyl)lysyl-L-tryptophyl-L-phenylalaninamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-(4-carboxybutanethioyl)lysyl-L-tyrosinamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-(4-carboxybutanethioyl)lysyl-N-propan-2-yl-D-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-(4-carboxybutanethioyl)lysyl-N-propan-2-yl-L-alaninamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-(4-carboxybutanethioyl)lysyl-N-propan-2-yl-L-prolinamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-(4-carboxybutanethioyl)lysyl-N-propan-2-yl-L-tryptophanamide | enzyme binding structure, crystal structure analysis | Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-(4-carboxybutanethioyl)lysyl-N-[(2S)-1,4-diamino-1-oxobutan-2-yl]-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-(4-carboxybutanethioyl)lysylglycinamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-ethanethioyl-L-lysyl-N-propan-2-yl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-[(2-carboxyethoxy)carbonyl]-L-lysyl-N-propan-2-yl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-[(2-carboxyethyl)carbamothioyl]-L-lysyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-[(2-carboxyethyl)carbamothioyl]-L-lysyl-N-adamantan-1-yl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-[(2-carboxyethyl)carbamothioyl]-L-lysyl-N-cyclopropyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-[(2-carboxyethyl)carbamothioyl]-L-lysyl-N-propan-2-yl-L-tryptophanamide | enzyme binding structure, crystal structure analysis | Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-[(2-carboxyethyl)carbamothioyl]-L-lysyl-N-[(2S)-1-methoxy-3-phenylpropan-2-yl]-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-[(2-carboxyethyl)carbamoyl]-L-lysyl-N-propan-2-yl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-[(3R)-4-carboxy-3-methylbutanoyl]-L-lysyl-N-propan-2-yl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-[(3S)-4-carboxy-3-methylbutanoyl]-L-lysyl-N-propan-2-yl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N2-[(benzyloxy)carbonyl]-N6-[(carboxymethyl)carbamothioyl]-L-lysyl-N-propan-2-yl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N6-[(2-carboxyethyl)carbamothioyl]-N2-(3-fluorobenzene-1-sulfonyl)-L-lysyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N6-[(2-carboxyethyl)carbamothioyl]-N2-(3-fluorobenzene-1-sulfonyl)-L-lysyl-N-cyclobutyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N6-[(2-carboxyethyl)carbamothioyl]-N2-(3-fluorobenzene-1-sulfonyl)-L-lysyl-N-cyclopentyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N6-[(2-carboxyethyl)carbamothioyl]-N2-(3-fluorobenzene-1-sulfonyl)-L-lysyl-N-cyclopropyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N6-[(2-carboxyethyl)carbamothioyl]-N2-(3-phenylpropanoyl)-L-lysyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N6-[(2-carboxyethyl)carbamothioyl]-N2-(4-methoxybenzene-1-sulfonyl)-L-lysyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N6-[(2-carboxyethyl)carbamothioyl]-N2-(4-nitrobenzene-1-sulfonyl)-L-lysyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N6-[(2-carboxyethyl)carbamothioyl]-N2-(naphthalene-2-sulfonyl)-L-lysyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N6-[(2-carboxyethyl)carbamothioyl]-N2-(phenylacetyl)-L-lysyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N6-[(2-carboxyethyl)carbamothioyl]-N2-(phenylcarbamoyl)-L-lysyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N6-[(2-carboxyethyl)carbamothioyl]-N2-(quinoline-8-sulfonyl)-L-lysyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N6-[(2-carboxyethyl)carbamothioyl]-N2-[4-(trifluoromethyl)benzene-1-sulfonyl]-L-lysyl-L-tryptophanamide | - |
Homo sapiens | |
2.3.1.B43 | N6-[N-[(benzyloxy)carbonyl]-L-gamma-glutamyl]-N2-[(benzyloxy)carbonyl]-L-lysyl-N-propan-2-yl-L-tryptophanamide | - |
Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.B43 | mitochondrion | - |
Homo sapiens | 5739 | - |
2.3.1.B43 | mitochondrion | - |
Danio rerio | 5739 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.B43 | NAD+ + [protein]-N6-succinyl-L-lysine | Homo sapiens | - |
nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose | - |
? | |
2.3.1.B43 | NAD+ + [protein]-N6-succinyl-L-lysine | Danio rerio | - |
nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.B43 | Danio rerio | Q6DHI5 | - |
- |
2.3.1.B43 | Homo sapiens | Q9NXA8 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.B43 | NAD+ + [protein]-N6-succinyl-L-lysine | - |
Homo sapiens | nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose | - |
? | |
2.3.1.B43 | NAD+ + [protein]-N6-succinyl-L-lysine | - |
Danio rerio | nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.B43 | hSIRT5 | - |
Homo sapiens |
2.3.1.B43 | SIRT5 | - |
Homo sapiens |
2.3.1.B43 | SIRT5 | - |
Danio rerio |
2.3.1.B43 | sirtuin 5 | - |
Homo sapiens |
2.3.1.B43 | sirtuin 5 | - |
Danio rerio |
2.3.1.B43 | sirtuin 5 deacylase | - |
Homo sapiens |
2.3.1.B43 | sirtuin 5 deacylase | - |
Danio rerio |
2.3.1.B43 | sirtuin-5 | - |
Danio rerio |
2.3.1.B43 | zSIRT5 | - |
Danio rerio |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.B43 | NAD+ | - |
Homo sapiens | |
2.3.1.B43 | NAD+ | - |
Danio rerio |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.3.1.B43 | evolution | sirtuins are a family of NAD+-dependent silent information regulator 2 (Sir2) enzymes that catalyze the removal of acyl groups from epsilon-N-amino groups of lysine residues in the proteome | Homo sapiens |
2.3.1.B43 | evolution | sirtuins are a family of NAD+-dependent silent information regulator 2 (Sir2) enzymes that catalyze the removal of acyl groups from epsilon-N-amino groups of lysine residues in the proteome | Danio rerio |